Peer-reviewed veterinary case report
Effects of Sodium Silicate Complex against Hemorrhagic Activities Induced byVenom.
- Journal:
- Toxins
- Year:
- 2021
- Authors:
- Chen, Yen-Chia et al.
- Affiliation:
- Emergency Department
- Species:
- rodent
Abstract
poses a serious medical threat to humans in Southern and Southeastern Asia. Hemorrhage is one of the conspicuous toxicities related to the pathology ofenvenoming. Previous in vitro and in vivo studies showed that a silica-derived reagent, sodium silicate complex (SSC), was able to neutralize hemorrhagic and proteolytic activities induced by pit viper venoms, including,and. In this study, we validated that SSC could neutralize enzymatic and toxic effects caused by the venom of. We found that SSC inhibited the hemolytic and proteolytic activities induced byvenom in vitro. In addition, we demonstrated that SSC could block intradermal hemorrhage caused byvenom in a mouse model. Finally, SSC could neutralize lethal effects ofvenom in the mice. Therefore, SSC is a candidate for further development as a potential onsite first-aid treatment forenvenoming.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33466634/