Peer-reviewed veterinary case report
Vitamin D levels drop temporarily after cruciate surgery in dogs
By Clements, Dylan N et al.·Published in Journal of veterinary internal medicine·2020·Royal (Dick) School of Veterinary Studies and The Roslin Institute, United Kingdom·View original on PubMed →
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Original publication title: Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs.
- Species:
- dog
Plain-English summary
A group of 17 dogs with a torn cranial cruciate ligament (CCL) underwent surgery and had their vitamin D levels checked before and after the procedure. After surgery, the total vitamin D levels dropped significantly but began to recover by day 60, while the free vitamin D levels increased right after surgery before declining again. This study highlights the challenges in understanding vitamin D levels in dogs after surgery, which can fluctuate during recovery.
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Abstract
BACKGROUND: It is unclear whether a low total 25(OH)D concentration is a cause or consequence of illnesses. To address this knowledge gap, studies measuring free and total 25(OH)D during the evolution and resolution of an inflammatory process are required. OBJECTIVES: Serum total and free 25(OH)D concentrations would transiently decline after cruciate surgery in dogs. ANIMALS: Seventeen client-owned dogs with a spontaneous cranial cruciate ligament rupture (CCLR). METHODS: A longitudinal cohort study involving the measurement of serum concentrations of total and free 25(OH)D, total calcium, creatinine, albumin, phosphate, C-reactive protein and plasma ionized calcium, at 1 day before and a median time of 1 and 60 days after surgical treatment of CCLR. RESULTS: Median serum concentrations of total 25(OH)D before surgery (80.3 nmoL/L [range, 43.5-137.3]) significantly declined immediately after surgery; (64.8 nmoL/L [range, 36.3-116.5] 1 day after surgery, P < .005) before increasing to become nonsignificantly different from concentrations before surgery at day 60 after surgery (median 78.0 nmoL/L [range, 24.2-115.8], P = .14). In contrast, median free 25(OH)D concentrations before surgery (7.6 pg/mL [range, 3.8-12.2]) significantly increased immediately after surgery (9.2 pg/mL [range, 5.2-15.7], P < .05) before declining to become nonsignificantly different from before surgery concentrations at day 60 after surgery (median 6.2 pg/mL [range, 4.0-15.8], P = .37). CONCLUSION AND CLINICAL IMPORTANCE: This study reveals the difficulties of assessing vitamin D status in dogs following elective surgery.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33179819/