Peer-reviewed veterinary case report
How skin severity and infection affect blood proteins in dogs
By Dinler Ay, Ceren et al.·Published in Veterinary dermatology·2022·Department of Internal Medicine·View original on PubMed →
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Original publication title: Effects of the clinical severity of disease and concomitant pyoderma on serum acute-phase proteins concentrations in dogs with sarcoptic mange.
- Species:
- dog
Plain-English summary
A group of 40 dogs with sarcoptic mange, a skin condition caused by mites, was studied to see how the severity of their symptoms affected certain blood proteins. The dogs were divided into groups based on how severe their skin lesions were, with some also having a secondary skin infection called pyoderma. The results showed that dogs with more severe mange had higher levels of specific proteins in their blood, which can indicate inflammation. Notably, the presence of pyoderma was linked to even higher levels of C-reactive protein, suggesting it could be a useful marker for veterinarians to identify this complication in dogs with severe mange.
People also search for: dog sarcoptic mange treatment · dog skin infection symptoms · how to treat pyoderma in dogs
Abstract
BACKGROUND: Information on acute-phase protein (APP) concentrations in dogs with sarcoptic mange (SM) is scarce. OBJECTIVE: To determine the effects of the clinical severity of disease and concomitant pyoderma on serum C-reactive protein (CRP), serum amyloid-A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) concentrations in dogs with SM. ANIMALS: Forty client-owned dogs with SM (INF group) and 10 healthy control dogs (CON group). MATERIALS AND METHODS: The INF group was divided into three subgroups; Group 1 (mild/moderate), Group 2 (severe) and Group 3 (severe+pyoderma) according to the extent of skin lesions and the presence of concomitant pyoderma. Serum CRP, SAA, Hp and Cp concentrations of all study groups were measured. RESULTS: Serum CRP (P < 0.001), SAA (P < 0.001) and Hp (P = 0.016) concentrations of the INF group were higher than the CON group, with no difference in terms of Cp. A statistical difference was measured between groups 2 and 1 in SAA only. C-reactive protein was found to be significantly higher in dogs with severe SM accompanied by pyoderma (Group 3) when compared with dogs with severe SM (Group 2). The area under the receiver-operating characteristic curves differentiating pyoderma among dogs with severe SM was 0.850 for CRP (P = 0.0001, cut-off value >61.3 mg/L with sensitivity 69.29% and specificity 90.91%). CONCLUSIONS: The unique findings in this were that the SAA serum concentrations are related to the severity of SM and that serum CRP concentrations are effective in detecting the presence of pyoderma in dogs with severe SM.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35670652/