Peer-reviewed veterinary case report
Maropitant does not speed up stomach emptying in healthy dogs
By Schmitz, Silke et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2016·Silke Schmitz, Germany·View original on PubMed →
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Original publication title: Effects of the neurokinin-1 antagonist maropitant on canine gastric emptying assessed by radioscintigraphy and breath test.
- Species:
- dog
Plain-English summary
A group of healthy adult Beagle dogs was tested to see if the medication maropitant could help with delayed gastric emptying, a condition where food takes longer to leave the stomach. The dogs received either maropitant, another medication called cisapride, or a placebo for a week, and their gastric emptying was measured using special imaging and breath tests. The results showed that neither maropitant nor cisapride improved gastric emptying compared to the placebo. Therefore, these medications are not recommended for this issue in dogs.
People also search for: dog delayed gastric emptying treatment · maropitant for dogs · cisapride for dog stomach issues
Abstract
OBJECTIVE: Delayed gastric emptying is a well-recognised phenomenon in a number of canine disease conditions. Only a limited number of drugs have been reported to have some gastrokinetic effect in the dog. The aim of this study was to investigate prokinetic effects of maropitant. MATERIAL AND METHODS: In a cross-over study 24 healthy adult Beagle dogs were randomised to receive either maropitant (2 mg/kg q24 h PO), cisapride (1 mg/kg q12 h PO) or placebo (vitamin-B12, 10 µg/dog q24 h PO) for 7 days with a 7-day washout period between treatments. Gastric emptying was measured simultaneously via 99mTechnetium radioscintigraphy and 13C-sodium acetate breath testing for 6 hours post-feeding. The decrease in radioactive counts in the stomach and the increase in 13CO2 concentration in exhaled breath (measured via gas chromatography) were plotted against time. The area under the curve was determined for each test and the time to 25%, 50% and 75% gastric emptying was calculated for each method. Friedman test was used to compare gastric emptying times. RESULTS: With both methods, no difference for gastric emptying times was observed for any treatment. CONCLUSION AND CLINICAL RELEVANCE: Neither maropitant nor cisapride were shown to have an effect on gastric emptying in healthy beagles using radioscintigraphy or breath test when compared to placebo. Consequently, neither drug can be recommended as a gastric prokinetic in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27090486/