Peer-reviewed veterinary case report
Eye pressure changes in normal cats after dorzolamide and timolol
By Dietrich, Ursula M et al.·Published in Veterinary ophthalmology·2007·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Effects of topical 2% dorzolamide hydrochloride alone and in combination with 0.5% timolol maleate on intraocular pressure in normal feline eyes.
- Species:
- cat
Plain-English summary
A group of healthy Domestic Short-haired cats had their eye pressure measured to see how well a topical medication called dorzolamide worked. The cats received either dorzolamide alone or in combination with another medication, timolol, over several days. The results showed that dorzolamide effectively lowered eye pressure, but the combination with timolol didn't provide a significantly better result than using dorzolamide alone. This means that while dorzolamide is helpful for managing eye pressure in cats, using both medications together may not be necessary for better results.
People also search for: cat eye pressure treatment · dorzolamide for cats · timolol for cat eye problems
Abstract
OBJECTIVE: To evaluate the effect of topical 2% dorzolamide alone, and in combination with topical 0.5% timolol, on intraocular pressure (IOP) in normal cats. ANIMALS: Twenty-four healthy Domestic Short-haired cats. PROCEDURE: Baseline values of IOP were established at 7 am, 10 am, 1 pm, 5 pm and 9 pm during pretreatment phase (days 1-2). During treatment phase (days 3-10) cats received 2% dorzolamide HCl q 12 h in group A (n = 6), q 8 h in group B (n = 6), and combined with 0.5% timolol maleate q 12 h in group C (n = 6). Cats in control group D (n = 6) received artificial tears q 8 h. During treatment phase IOP measurements were continued at the same time-points as in the pretreatment phase. RESULTS: Mean pretreatment IOP in all cats was 18.46 +/- 2.99 mmHg. Mean IOP decreased significantly (P < 0.0086) in all treatment groups compared to pretreatment values (group A: 16.40 +/- 0.49 mmHg, group B: 16.04 +/- 0.49 mmHg, group C: 17.76 +/- 0.49 mmHg). IOP did not decrease in control group D (18.55 +/- 0.49 mmHg). The difference in IOP between treatment groups (A, B, C) was not statistically significant, but comparison of IOP between each treatment group and the control group was statistically significant (A-D; P = 0.0057; B-D, P = 0.0012; C-D, P = 0.0212). CONCLUSION: Topical 2% dorzolamide significantly lowers IOP in normal cats but the effect is mild. Concomitant application of 2% dorzolamide and 0.5% timolol does significantly decrease IOP, but the effect is not significantly greater than q 8 h administration of dorzolamide alone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17973840/