Peer-reviewed veterinary case report
Effects of topical sesame oil on oxidative stress in rats.
- Journal:
- Alternative therapies in health and medicine
- Year:
- 2005
- Authors:
- Chiang, James Po-Jung et al.
- Affiliation:
- Department of Environmental and Occupational Health
- Species:
- rodent
Abstract
OBJECTIVE: To assess the effects of topical sesame oil on systemic oxidative stress in rats. DESIGN: Oxidative stress was induced with lipopolysaccharide and assessed by determining serum lipid peroxidation, superoxide anion, and hydroxyl radical levels. The levels of 3 circulating antioxidants--superoxide dismutase, catalase, and glutathione--also were determined. RESULTS: Topical sesame oil significantly reduced lipid peroxidation, superoxide anion, and hydroxyl radical levels after lipopolysaccharide administration. However, sesame oil did not affect the 3 circulating antioxidants. Further, sesame oil decreased the activity of xanthine oxidase and nitric oxide production in lipopolysaccharide-treated rats. CONCLUSION: Sesame oil given topically might attenuate oxidative stress by inhibiting the production of xanthine oxidase and nitric oxide in rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16320859/