Peer-reviewed veterinary case report
Effects of trimethoprim-sulfadiazine on thyroid function of horses.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 2004
- Authors:
- Rothschild, Chantal M et al.
- Affiliation:
- Department of Veterinary Clinical Sciences · United States
- Species:
- horse
Abstract
Trimethoprim-sulfadiazine was administered to horses in a randomized, placebo controlled study to determine the effects of potentiated sulfonamides on thyroid function in normal horses. The treatment group included eight horses that received trimethoprim-sulfadiazine mixed with molasses orally at 30 mg/kg once daily for eight weeks. The control group included 8 horses that received an oral placebo (flour mixed with molasses) once daily for the same period. Thyroid function was evaluated prior to initiation of treatment and after 8 weeks of treatment. Serum concentrations of total and free triiodothyronine (T3), total and free thyroxine (T4), and thyroid stimulating hormone (TSH) were determined at rest and after a thyrotropin-releasing hormone (TRH) stimulation test. There was no detectable difference between treatment and control groups.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15188829/