Peer-reviewed veterinary case report
Dietary supplements and inflammation in dog joint cells
By AlRaddadi, Eman A et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2019·Department of Pharmacology and Therapeutics·View original on PubMed →
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Original publication title: Effects of various dietary supplements on inflammatory processes in primary canine chondrocytes as a model of osteoarthritis.
- Species:
- dog
Plain-English summary
A study looked at how different dietary supplements could help reduce inflammation in dogs with osteoarthritis (OA). Researchers tested creatine and amino acid supplements alongside a common pain medication called carprofen and a joint supplement called glucosamine. While all the supplements showed some ability to lower inflammation markers, carprofen was less effective and even increased one inflammation marker. The findings suggest that creatine and amino acids might be helpful in managing joint inflammation, but more research is needed to confirm their benefits for dogs with OA.
People also search for: dog osteoarthritis supplements · creatine for dogs joint pain · carprofen side effects in dogs
Abstract
The use of dietary supplements as an alternative treatment for joint-related pathologies such as osteoarthritis (OA) is increasing. However, there is little scientific evidence to support the intended use. The aim of this study was to evaluate the anti-inflammatory effects of creatine- and amino acid-based supplements in primary cultured canine chondrocytes (CnCs) as anmodel of OA and compare the effects to more commonly used agents, such as the non-steroidal anti-inflammatory drug (NSAID), carprofen, and the joint supplement, glucosamine (GS). CnCs were stimulated with interleukin-1β (IL-1β) and the subsequent release of prostaglandin E2 (PGE2) and tumor necrosis factor alpha (TNFα) was measured using an enzyme-linked immunosorbent assay (ELISA). Changes in oxylipins were also assessed using high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). All compounds examined were able to significantly reduce the release of PGE2 and TNFα and were associated with reductions in cyclooxygenase-2 (COX-2) expression and nuclear factor-kappaB (NF-κB) phosphorylation. The creatine- and amino acids-based supplements also altered the profile of oxylipins produced. All compounds examined were less effective at reducing the release of PGE2 than carprofen. Carprofen significantly increased release of TNFα from CnCs, however, while the other agents reduced TNFα release. This study suggests that creatine- and amino acid-based supplements may have a beneficial role in preventing inflammation within the joint and that further studies are warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31308593/