Peer-reviewed veterinary case report
Zinc-L-carnosine and vitamin E reduce aspirin stomach injury in dogs
By Baan, M et al.Ā·Published in Journal of veterinary internal medicineĀ·2011Ā·Department of Medical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Effects of zinc-L-carnosine and vitamin E on aspirin-induced gastroduodenal injury in dogs.
- Species:
- dog
Plain-English summary
A group of healthy Foxhound dogs was given either a placebo or a combination of zinc-L-carnosine and vitamin E to see if it could help prevent stomach injuries caused by aspirin. After 35 days of treatment, all dogs showed signs of gastrointestinal damage, but the supplements did not significantly reduce the injuries compared to the placebo group. This means that the combination of zinc-L-carnosine and vitamin E did not provide the expected protection against aspirin-related stomach issues in these dogs.
People also search for: dog aspirin stomach injury Ā· zinc-L-carnosine for dogs Ā· vitamin E for dog gastrointestinal health
Abstract
BACKGROUND: Nonsteroidal anti-inflammatory drugs frequently cause gastrointestinal (GI) injury. Zinc-L-carnosine has antioxidant, anti-inflammatory, mucosal protective, and healing properties in rodent models and in some human studies of GI injury. HYPOTHESIS: The combination of zinc-L-carnosine and vitamin E attenuates aspirin-induced gastroduodenal mucosal injury. ANIMALS: Eighteen healthy random-source Foxhound dogs. METHODS: In this randomized, double-blinded, placebo-controlled study dogs were treated with placebo (n = 6; 0X group), 30 mg/30 IU (n = 6; 1X group), or 60 mg/60 IU (n = 6; 2X group) zinc-L-carnosine/vitamin E orally every 12 hours for 35 days. Between Day 7 and 35, GI mucosal lesions were induced with aspirin (25 mg/kg p.o. q8h). Mucosal injury lesions (hemorrhage, erosion, and ulcer) were assessed by gastroduodenoscopy on Days 14, 21, and 35 with a 12-point scoring scale. RESULTS: At baseline (Day -1) gastroscopy scores were not significantly different between groups (mean ± SD: 0X, 4.4 ± 0.8; group 1X, 4.4 ± 0.6; group 2X, 4.2 ± 0.3; P= .55). Gastroscopy scores increased significantly in all groups between Day -1 and Days 14, 21, and 35 (P < .0001). On Day 35, gastroscopy scores were 29.2 ± 5.2 (0X), 27.3 ± 3.7 (1X), and 28.6 ± 3.3 (2X). Mean gastroscopy scores were not significantly different among treatment groups on any of the days (P = .61). CONCLUSIONS AND CLINICAL IMPORTANCE: Administration of the combination of zinc-L-carnosine and vitamin E at 1X or 2X dosing did not attenuate aspirin-induced gastroduodenal mucosal injury.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21092006/