Effects ofInstead of Antibiotics on Growth Performance, Intestinal Health, and Intestinal Microbiota of Broilers.

Abstract

The aim of this study was to evaluate the dietary effects ofSC06 (SC06) instead of antibiotics on the growth performance, intestinal health, and intestinal microbiota of broilers. A total of 360 30-day-old Lingnan yellow broilers were randomly allocated into two groups with six replicates per group (30 birds per replicate). The broilers were fed either a non-supplemented diet or a diet supplemented with 10colony-forming units lyophilized SC06 per kilogram feed for 30 days. Results showed that SC06 supplementation had no effect on the growth performance compared with that of the control group. SC06 treatment significantly (<0.05) increased the total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD) activity in the liver, and the activities of trypsin, &#x3b1;-amylase (AMS), and NaK-ATPase in the ileum, whereas it decreased (< 0.05) lipase, gamma glutamyl transpeptidase (&#x3b3;-GT), and maltase activities in the ileum. Meanwhile, SC06 treatment also improved the immune function indicated by the significantly (< 0.05) increased anti-inflammatory cytokine [interleukin (IL)-10] level and the decreased (< 0.05) pro-inflammatory cytokine [IL-6 and tumor necrosis factor (TNF)-&#x3b1;] levels in the ileum. Furthermore, we also found that SC06 enhanced the intestinal epithelial intercellular integrity (tight junction and adhesion belt) in the ileum. Microbial analysis showed that SC06 mainly increased the alpha diversity indices in the jejunum, ileum, and cecum. SC06 treatment also significantly (< 0.05) increased the abundances of, andin the cecum and simultaneously decreased the abundances ofin the duodenum,in the jejunum, andandin cecum. In conclusion, these results suggested thatinstead of antibiotics showed a potential beneficial effect on the intestinal health of broilers.