Peer-reviewed veterinary case report
Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2019
- Authors:
- Tanner, Lloyd et al.
- Affiliation:
- Department of Medicine
Abstract
, the causative agent of tuberculosis, remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such as clofazimine are clinically efficacious against both drug-susceptible and drug-resistant strains ofWe determined theanti-activities, absorption, distribution, metabolism, and excretion properties, andmouse pharmacokinetics of a series of structurally related phenoxazines. One of these, PhX1, displayed promising drug-like properties and potentefficacy, supporting its further investigation in an-infected animal model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31427302/