Peer-reviewed veterinary case report
Lenziaren oral phosphate binder lowers urine phosphate in healthy cats
By King, Jonathan N et al.·Published in BMC veterinary research·2014·View original on PubMed →
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Original publication title: Efficacy, acceptability and tolerability of the new oral phosphate binder Lenziaren® in healthy cats fed a standard diet.
- Species:
- cat
Plain-English summary
A study found that a new oral phosphate binder called Lenziaren was effective in reducing phosphate levels in the urine of healthy cats. The cats were given a standard diet with added Lenziaren for 30 days, and those receiving doses of 0.5 to 2.0 grams per day showed significant reductions in urine phosphate compared to those not receiving the treatment. Lenziaren was well tolerated, and the cats even ate more food and had higher iron levels. This suggests that Lenziaren could be a good option for managing phosphate levels in cats without causing weight loss.
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Abstract
BACKGROUND: The efficacy, acceptability and tolerability of the new oral phosphate binder Lenziaren® (SBR759) were evaluated in a randomized parallel-group design study in 36 healthy cats (n = 6 per group). Five groups were fed once daily with a commercial diet containing 0.2% phosphorus ("standard diet") into which was mixed Lenziaren® at 0.25, 0.5, 1.0 or 2.0 g/day or no treatment (control group) daily for 30 days. A sixth group was fed a commercial diet containing lower amounts (0.12%) of phosphorus ("renal diet") and no treatment. RESULTS: When compared to the control group, Lenziaren® produced significant dose-related reductions in urine phosphate concentrations, urine phosphate excretion and fractional urinary phosphate excretion. Significant effects versus the control group were observed at the 0.5, 1.0 and 2.0 g/day dosages. Lenziaren® was well tolerated and was associated with higher food consumption and serum iron concentrations versus the control. When compared to the control group, the renal diet was associated with significantly lower urine phosphate concentrations and loss of body weight. Lenziaren® had similar effects on urine phosphate concentrations compared to the renal diet, but was not associated with loss of body weight. CONCLUSIONS: Lenziaren® was effective as an oral phosphate binder in cats fed with a standard diet containing 0.2% phosphorus. The acceptability and tolerability were good. Dosages of 0.5-1.0 g/cat per day are recommended for clinical testing in cats fed with a standard diet.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25348573/