Peer-reviewed veterinary case report
Permethrin-Fipronil Spot-On Controls Tick Infestations in Dogs
By Navarro, Christelle et al.·Published in BioMed research international·2016·Virbac, France·View original on PubMed →
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Original publication title: Efficacy and Safety of a Permethrin-Fipronil Spot-On Solution (Effitix®) in Dogs Naturally Infested by Ticks in Europe.
- Species:
- dog
Plain-English summary
A group of dogs in Europe with tick infestations were treated with a new spot-on solution called Effitix, which combines fipronil and permethrin. Over four weeks, the treatment showed impressive effectiveness, reducing tick counts by over 91% within just a week and maintaining high efficacy throughout the study. The dogs experienced very few side effects, mostly mild itching, and overall, Effitix proved to be a safe and effective option for controlling ticks.
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Abstract
Effitix is a new broad spectrum product based on the combination of fipronil 6.1% and permethrin 54.5% in a solution for spot-on application. It has been shown to be safe and efficacious in dogs in controlling tick, flea, sandfly, and mosquito infestations in laboratory conditions. The aim of this controlled, randomised study was to assess its safety and efficacy against natural tick infestations in field conditions. One hundred eighty-two privately owned dogs were included in France and Germany: 123 dogs were treated on day 0 with the permethrin-fipronil combination (Effitix) and 59 with a permethrin-imidacloprid combination (Advantix®). Tick counts were conducted on days 0 (before treatment), 7, 14, 21, and 28. The percentages of efficacy on days 7, 14, 21, and 28 were, respectively, 91.2%, 97%, 98.3%, and 96.7% with Effitix and were 94.8%, 96.9%, 95.7%, and 94.6% with Advantix. Very few adverse events were reported. Most were not serious and/or not related to the treatment with pruritus being the most common. One administration of Effitix was highly effective and safe to treat and control tick infestations for four weeks in field conditions and had a similar efficacy as the permethrin-imidacloprid combination for all visits.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27703984/