Peer-reviewed veterinary case report
Purified porcine insulin safely controls diabetes in dogs
By Monroe, William E et al.·Published in Journal of veterinary internal medicine·2005·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Efficacy and safety of a purified porcine insulin zinc suspension for managing diabetes mellitus in dogs.
- Species:
- dog
Plain-English summary
A group of 53 dogs with diabetes were treated with a special insulin to help manage their blood sugar levels. Over 60 days, the dogs showed significant improvements, with many experiencing less frequent urination, thirst, and ketones in their urine. By the end of the study, most dogs had better blood glucose control, and while some needed insulin injections every 12 hours, the treatment was generally safe with few side effects. This insulin therapy effectively helped these dogs feel better and manage their diabetes.
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Abstract
The objective of this study was to evaluate the safety and efficacy of a purified porcine insulin zinc suspension for treating dogs with uncomplicated diabetes mellitus. Fifty-three dogs were treated for 60 days after an initial dose determination period. The means of the blood glucose concentrations during 12-hour glucose curves and the means of the blood glucose nadir concentrations during 12-hour glucose curves for all dogs were determined before beginning insulin therapy (time 0), at the end of the dose determination period (time 1), 30 days after time 1 (time 2), and 60 days after time 1 (time 3). Presence of polyuria, polydipsia, and ketonuria was determined at each time point. Adequacy of control of hyperglycemia was based on 12-hour blood glucose curves and improvement in clinical variables (results of physical examinations, historic information, polyuria, polydipsia, and ketonuria). Safety was evaluated by questionnaire, performance of physical examination, CBC, serum chemistry profile, and urinalysis. The means of the blood glucose concentrations during 12-hour glucose curves and the means of the blood glucose nadir concentrations during 12-hour glucose curves for all dogs at times 1, 2, and 3 were significantly lower compared with time 0 (P < .0001). There was a reduction in the proportion of dogs with polyuria, polydipsia, and ketonuria of 82, 86, and 80%, respectively. All of the dogs had adequate glycemic control at time 1, 66% at time 2, and 75% at time 3. At time 3, 66% of dogs required insulin injections q12h. Other than hypoglycemia, there were no important adverse effects of insulin administration. The insulin, was safe and efficacious for reducing blood glucose and clinical signs in dogs with diabetes mellitus.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16231711/