Peer-reviewed veterinary case report
Electrochemotherapy and IL-12 gene therapy control mast cell tumors
By Cemazar, M et al.·Published in Veterinary and comparative oncology·2017·Department of Experimental Oncology·View original on PubMed →
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Original publication title: Efficacy and safety of electrochemotherapy combined with peritumoral IL-12 gene electrotransfer of canine mast cell tumours.
- Species:
- dog
Plain-English summary
Eighteen dogs with mast cell tumors were treated using a combination of electrochemotherapy and a special gene therapy that helps boost the immune response. After one month, the treatment showed good results, with 72% of the tumors responding completely and no side effects reported. The therapy not only controlled the tumors effectively but also helped prevent them from coming back or spreading to other parts of the body. This approach appears to be both safe and effective for treating these types of tumors in dogs.
People also search for: dog mast cell tumor treatment · electrochemotherapy for dogs · IL-12 gene therapy for canine tumors
Abstract
Electrochemotherapy combined with peritumoral interleukin-12 (IL-12) gene electrotransfer was used for treatment of mast cell tumours in 18 client-owned dogs. Local tumour control, recurrence rate, as well as safety of combined therapy were evaluated. One month after the therapy, no side effects were recorded and good local tumour control was observed with high complete responses rate which even increased during the observation period to 72%. IL-12 gene electrotransfer resulted in 78% of patients with detectable serum IFN-γ and/or IL-12 levels. In the treated tumours vascular changes as well as minimal T-lymphocytes infiltration was observed. After 1 week, the plasmid DNA was not detected intra- or peritumorally and no horizontal gene transfer was observed. In summary, our study demonstrates high antitumour efficacy of electrochemotherapy combined with IL-12 electrotransfer, which also prevented recurrences or distant metastases, as well as its safety and feasibility in treatment of canine mast cell tumours.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26840222/