Peer-reviewed veterinary case report
UC-II collagen treatment reduces arthritis pain in obese dogs
By Deparle, L A et al.·Published in Journal of veterinary pharmacology and therapeutics·2005·Murray State University, United States·View original on PubMed →
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Original publication title: Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs.
- Species:
- dog
Plain-English summary
A group of large breed dogs with arthritis were given either a collagen supplement (UC-II) or no treatment for 90 days to see how it affected their pain and lameness. The dogs that received UC-II showed significant improvements in pain levels and were more active, especially those on the higher dose of 10 mg per day. After stopping the supplement, the dogs experienced a return of their pain and lameness symptoms. Overall, UC-II was found to be safe and effective for managing arthritis in these dogs.
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Abstract
DeParle L. A., Gupta R. C., Canerdy T. D., Goad J. T., D'Altilio M., Bagchi M., Bagchi D. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. J. vet. Pharmacol. Therap.28, 385-390. In large breed dogs, arthritis is very common because of obesity, injury, aging, immune disorder, or genetic predispositions. This study was therefore undertaken to evaluate clinical efficacy and safety of undenatured type-II collagen (UC-II) in obese-arthritic dogs. Fifteen dogs in three groups received either no UC-II (Group I) or UC-II with 1 mg/day (Group II) or 10 mg/day (Group III) for 90 days. Lameness and pain were measured on a weekly basis for 120 days (90 days treatment plus 30 days post-treatment). Blood samples were assayed for creatinine and blood urea nitrogen (markers of renal injury); and alanine aminotransferase and aspartate aminotransferase (evidence of hepatic injury). Dogs receiving 1 mg or 10 mg UC-II/day for 90 days showed significant declines in overall pain and pain during limb manipulation and lameness after physical exertion, with 10 mg showed greater improvement. At either dose of UC-II, no adverse effects were noted and no significant changes were noted in serum chemistry, suggesting that UC-II was well tolerated. In addition, dogs receiving UC-II for 90 days showed increased physical activity level. Following UC-II withdrawal for a period of 30 days, all dogs experienced a relapse of overall pain, exercise-associated lameness, and pain upon limb manipulation. These results suggest that daily treatment of arthritic dogs with UC-II ameliorates signs and symptoms of arthritis, and UC-II is well tolerated as no adverse effects were noted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16050819/