Peer-reviewed veterinary case report
Renal sympathetic denervation helps dogs with pressure overload heart
By Chen, Pingan et al.·Published in Heart, lung & circulation·2017·Department of Cardiology, China·View original on PubMed →
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Original publication title: Efficacy and Safety of Renal Sympathetic Denervation on Dogs with Pressure Overload-Induced Heart Failure.
- Species:
- dog
Plain-English summary
A group of dogs with heart failure caused by pressure overload underwent a procedure called renal sympathetic denervation (RSD) to see if it could help improve their heart function. After eight weeks, the dogs that received RSD showed lower levels of certain stress hormones and improved heart measurements compared to those that did not have the procedure. Importantly, the RSD did not harm the renal arteries. This suggests that RSD could be a safe and effective treatment option for dogs suffering from this type of heart failure.
People also search for: dog heart failure treatment · renal sympathetic denervation dogs · improving heart function in dogs
Abstract
BACKGROUND: In dogs with heart failure (HF) induced by overload pressure, the role of renal sympathetic denervation (RSD) on heart failure and in the renal artery is unclear. Therefore, we investigated the efficacy and safety of RSD in dogs with pressure overload-induced heart failure. METHODS: Twenty mongrel dogs were divided into a sham-operated group, an HF group and an HF + RSD group. In the sham-operated group, the abdominal aorta was located but was not constricted, in the HF group, the abdominal aorta was constricted without RSD, and the HF+RSD group underwent RSD with constriction of the abdominal aorta after 10 weeks. Blood sampling assays, echocardiography, intravascular ultrasound (IVUS) measurement and histopathological examination were performed. RESULTS: Renal sympathetic denervation caused a significant reduction in the levels of noradrenaline (166.62±6.84 vs. 183.48±13.66 pg/ml, P<0.05), plasma renin activity (1.93±0.12 vs. 2.10±0.13 ng/mlh, P<0.05) and B-type natriuretic peptide (71.14±3.86 vs. 83.15±5.73 pg/ml, P<0.05) at eight weeks after RSD in the HF+RSD group. Compared with the HF group at eight weeks, the left ventricular internal dimension at end-diastole and end-systole were lower and the left ventricular ejection fraction was higher (all P<0.05) at eight weeks after RSD in the HF+RSD group. Intravenous ultrasound images showed no changes in the renal artery lumen, and intimal hyperplasia and vascular lumen stenosis were not observed after RSD. CONCLUSIONS: Renal sympathetic denervation could improve cardiac function in dogs with HF induced by pressure overload; RSD had no adverse influence on the renal artery.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27555054/