Peer-reviewed veterinary case report
New inactivated vaccine protects cats from Chlamydophila felis
By Masubuchi, Katsuo et al.·Published in Journal of feline medicine and surgery·2010·Kyoto Biken Laboratories, Japan·View original on PubMed →
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Original publication title: Efficacy of a new inactivated Chlamydophila felis vaccine in experimentally-infected cats.
- Species:
- cat
Plain-English summary
A group of cats was tested with a new vaccine designed to protect against Chlamydophila felis, a bacteria that can cause respiratory and eye problems. The cats that received this new vaccine showed strong immune responses and had only mild symptoms after being exposed to the bacteria, while those given older vaccines did not fare as well. Importantly, the new vaccine did not cause any side effects in the cats. This suggests that the new vaccine could be a good option for preventing Chlamydophila felis infections in cats.
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Abstract
A new inactivated and adjuvanted Chlamydophila felis vaccine was developed and its efficacy in cats was compared with that of commercially available inactivated and live vaccines. Two commercial vaccines conferred insufficient immunity on inoculated cats, as evaluated by antibody production and a challenge experiment, whereas cats administered the newly generated vaccine produced high-titre antibodies and acquired sufficient immunity. The cats immunised with the new vaccine revealed no or only mild clinical signs, and no chlamydiae were recovered from their tissue samples after exposure to a virulent C felis. However, they shed chlamydiae in their nasal and conjunctival secretions after challenge, as did those immunised with the commercial vaccines and the non-vaccinated controls. The newly developed vaccine caused no adverse reaction in the inoculated cats. These findings suggest that the new vaccine prepared here may be promising for practical use in controlling C felis infection in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20472483/