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Peer-reviewed veterinary case report

Single-dose topical treatment kills ear mites, mange, and lice in cats

By Campos, Diefrey Ribeiro et al.·Published in Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria·2026·Universidade Federal Rural Rio de Janeiro, Brazil·View original on PubMed

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Original publication title: Efficacy of a single-dose topical formulation combining Fipronil, Moxidectin and Praziquantel against natural infestations of Notoedres cati, Otodectes cynotis and Felicola subrostratus in cats.

Species:
cat

Plain-English summary

A group of cats with lice and mange were treated with a single dose of a topical medication that combined fipronil, moxidectin, and praziquantel. This treatment was highly effective against common parasites like ear mites, and within just three days, all the cats showed no signs of infestation. The cats tolerated the treatment well, making it a safe option for dealing with these pesky parasites. If your cat is dealing with itching or skin problems due to parasites, this treatment could be worth discussing with your vet.

People also search for: cat itching treatment · cat ear mites medication · how to get rid of cat lice

Abstract

Lice and mange represent common ectoparasitic infestations in domestic cats, affecting their health and well-being. The study evaluated the efficacy of a topical formulation containing 12.5% fipronil + 0.83% moxidectin + 8.3% praziquantel against common feline ectoparasites Otodectes cynotis, Notoedres cati and Felicola subrostratus. For the ear mite study, a controlled trial was conducted on cats naturally infested with O. cynotis. For the other two parasites, field studies were conducted on naturally infested cats. Cats in the treated group received a single topical dose of formulation. Parasite counts were performed at various time points post-treatment to assess efficacy. The results demonstrated the formulation was highly effective against all three parasites, achieving 100% efficacy after 3 days of treatment. The product was well-tolerated and safe, making it a suitable option for the treatment of feline ectoparasitosis.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41983805/