Peer-reviewed veterinary case report
Topical fipronil, moxidectin, and praziquantel controls fleas on cats
By Campos, Diefrey Ribeiro et al.·Published in Frontiers in veterinary science·2025·Department of Animal Parasitology, Brazil·View original on PubMed →
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Original publication title: Efficacy of a topical formulation combining fipronil, moxidectin, and praziquantel (Banni3) in controlling flea infestation in cats.
- Species:
- cat
Plain-English summary
A group of cats with flea infestations were treated with a new topical product called Banni3, which contains fipronil, moxidectin, and praziquantel. The treatment was highly effective, showing a 100% success rate in eliminating fleas just two days after application, and it remained effective for several weeks. In a separate group of naturally infested cats, the product also demonstrated over 98% effectiveness in reducing flea counts within the first month. Overall, Banni3 was found to be a safe and effective option for controlling fleas in both artificially and naturally infested cats.
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Abstract
is the most common parasitic insect worldwide, responsible for transmitting pathogenic agents to cats. The aim of this study was to evaluate the efficacy of a novel formulation containing fipronil 12.5%, moxidectin 0.83%, and praziquantel 8.3%, in the treatment of cats, both artificially as well as naturally infested with. For the controlled study, 14 cats were divided into a control group that received no treatment and a treated group that received the investigational product (Banni3 - 12.5% fipronil + 0.83% moxidectin + 8.3% praziquantel - Ourofino Saúde Animal Ltda.). Each animal was artificially infested 48 h before each evaluation with 100 fleas. Evaluations to determine efficacy were based on the average count of live fleas found in the control and treated groups and were carried out nine times after treatment for 56 days. For the field study, 110 indoor cats, naturally infested with, were included. These animals were divided into the positive control group, which received a topical formulation of 10% fipronil, and the treated group which received the investigational product. The efficacy evaluations were based on the average number of live fleas found pre-treatment and post-treatment and were carried out on days four times after treatment 30 days. For artificially infested cats, there was a statistically significant difference (< 0.05) between the mean flea counts of the negative control and treated groups, and the efficacy was 100% from the second day up to 14 days after treatment, and then 99.3%, 97.8%, 96.0%, 92.0% and 92.5%, respectively, 21, 30, 35, 42 and 49 days after treatment. For cats that had natural infestations, the effectiveness was 98.6%, 99.7%, 98.7% and 97.3% on days 7, 14, 21 and 30 after treatment, respectively. There was no statistically significant difference (> 0.05) when comparing flea counts between the treated group and positive control, but there were statistically significant differences (< 0.05) in the pre- and post-treatment evaluations. A topical treatment with Banni3, administered as a single dose, is proven safe and effective for controllingin artificially and naturally infested cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40046424/