Peer-reviewed veterinary case report
Topical emodepside and praziquantel kill hookworms in cats
By Altreuther, G et al.·Published in Parasitology research·2005·Bayer HealthCare AG, Germany·View original on PubMed →
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Original publication title: Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats.
- Species:
- cat
Plain-English summary
A group of cats with hookworm infections (caused by Ancylostoma tubaeforme) were treated with a new spot-on medication that combines emodepside and praziquantel. This treatment was shown to be highly effective, eliminating nearly all adult and immature worms without causing any side effects. The cats received the treatment at a specific dose based on their weight, and the results indicated that this spot-on option could be a simpler and safer alternative to oral medications for treating these types of infections.
People also search for: cat hookworm treatment · emodepside praziquantel for cats · safe deworming for cats
Abstract
This paper reports the efficacy of emodepside/praziquantel spot-on (Profender), Bayer AG, Leverkusen, Germany), a novel broad-spectrum anthelmintic for dermal application, against L4 larvae and immature adult and adult stages of Ancylostoma tubaeforme in cats. The formulation contains 2.14% (w/w) emodepside and 8.58% (w/v) praziquantel, with emodepside being active against gastrointestinal nematodes and praziquantel against cestodes. Five randomized, blinded and controlled laboratory studies demonstrated 100% efficacy of emodepside/praziquantel spot-on against mature A. tubaeforme and an efficacy of >95% and >97%, respectively, against L4 larvae and immature adults (based on worm counts after necropsy) at approximately the minimum proposed dose rate in cats of 3.0 mg emodepside and 12.0 mg praziquantel/kg body weight. No adverse reactions to the treatment were observed. It is concluded that emodepside/praziquantel spot-on is an effective and safe treatment against infections with mature and immature A. tubaeforme. Emodepside/praziquantel spot-on will considerably facilitate the treatment of cats against nematodes and cestodes compared with orally administered preparations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16228275/