Efficacy of acupuncture therapy for post-stroke fatigue: a systematic review and Meta-analysis.

Abstract

<h4>Objective</h4>To assess the effectiveness and safety of acupuncture for post-stroke fatigue (PSF).<h4>Methods</h4>Eight online databases were searched to collect relevant trials of acupuncture for PSF published before April 2021. Meta-analysis was performed by using RevMan 5.4 software. The Grading of Recommendations, Assessment, Development and Evaluation system was used to assess the certainty of evidence.<h4>Results</h4>Four randomized controlled trials involving 289 PSF patients were identified and included in the systematic review. The results of the Meta-analysis revealed that acupuncture group was significantly better than routine treatment group in improving the effective rate [risk ratio () = 1.15, 95%(1.01, 1.33), = 0.04], reducing the FSS score [mean difference () =?－4.71, 95% ?(－6.22, －3.20), < 0.000 01] and FMA score [=?15.60, 95%?(11.96, 19.23), < 0.000 01]. Side effects of acupuncture were mild and rarely reported. The certainty of evidence of the outcomes based on the four trials was assessed as low.<h4>Conclusions</h4>The existing evidence suggests acupuncture as an adjunct to routine treatment may benefit in managing fatigue in stroke patients. However, high-quality RCTs are needed to further confirm these findings.