Peer-reviewed veterinary case report
How well afoxolaner works to control fleas on cats
By Machado, Marília Alves et al.·Published in Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria·2019·Programa de Pó, Brazil·View original on PubMed →
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Original publication title: Efficacy of afoxolaner in the flea control in experimentally infested cats.
- Species:
- cat
Plain-English summary
A group of 14 cats were tested for flea control after being infested with fleas. Half of the cats received a single oral dose of a medication called afoxolaner, while the other half received a placebo. The results showed that afoxolaner was highly effective, eliminating fleas completely within two days and maintaining over 95% effectiveness for up to nine weeks. Importantly, there were no side effects noted in any of the cats.
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Abstract
The aim of this study was to evaluate the efficacy of a single dose of oral afoxolaner in controlling fleas in cats. Fourteen cats were used. The cats were given identification numbers, housed individually, artificially infested with Ctenocephalides felis felis, and treated (or not) with afoxolaner. Were divided into a treatment group and a control group (n = 7/group), on the basis of the fleas count hours after an infestation applied on Day (one-by-one allocation after ordering by count). At the start of the experimental protocol (designated day 0), the treated group received afoxolaner in a single dose of 2.5 mg/kg and the control group animals received a placebo. All animals were infested with 100 C. felis felis fleas two days before day 0, as well as on days 5, 12, 19, 26, 33, 40, 47, 54, and 63, parasite loads being evaluated at 48 h after each infestation. The efficacy of afoxolaner was 100% on day 2 and remained above 98% until day 42, decreasing to 95.3% by day 63. The findings confirm that a single dose of oral afoxolaner was effective in controlling C. felis felis in cats, and there were no observed adverse events.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31483035/