Peer-reviewed veterinary case report
NexGard Spectra chewables kill adult hookworms in dogs
By Tielemans, E et al.·Published in Veterinary parasitology·2017·Merial SAS, France·View original on PubMed →
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Original publication title: Efficacy of afoxolaner plus milbemycin oxime chewable tablets (NexGard Spectra, Merial) against adult Ancylostoma ceylanicum hookworm, in dogs.
- Species:
- dog
Plain-English summary
A group of Beagle dogs was intentionally infected with hookworms and then treated with a chewable tablet containing afoxolaner and milbemycin oxime (NexGard Spectra). After treatment, only one dog had a few hookworms left, showing that the medication was 99.9% effective at getting rid of the parasites. The dogs tolerated the treatment well, and it was safe for them. This combination treatment could be a great option for pet owners looking to protect their dogs from hookworm infections.
People also search for: dog hookworm treatment · NexGard Spectra for dogs · Beagle hookworm symptoms
Abstract
A fixed-combination chewable tablet incorporating afoxolaner plus milbemycin oxime (NexGard Spectra, Merial) was tested in purpose-bred Beagle dogs for efficacy against adult Ancylostoma ceylanicum hookworms. Sixteen dogs were inoculated each by oral administration of approximately 500 infective larvae of A. ceylanicum. Seventeen days after inoculation, the dogs were weighed and allocated randomly to be treated with afoxolaner plus milbemycin oxime chewable tablets or to remain untreated. Commercial chewable tablets of different strength were combined to deliver doses as close as possible to the minimum effective dose of 2.5mg afoxolaner plus 0.5mg milbemycin oxime per kg body weight. Parasites were recovered and counted for determination of efficacy seven days after treatment. All eight dogs that had been left untreated were harboring adult A. ceylanicum (geometric mean, 317.8; range, 210-428) while only one and nine A. ceylanicum were recovered from two of the eight dogs treated with afoxolaner plus milbemycin oxime chewable tablets (geometric mean, 0.5; p<0.0001). Thus, 99.9% efficacy against induced infection of A. ceylanicum was obtained by the use of oral NexGard Spectraat the minimum effective dose. Treatment with afoxolaner plus milbemycin oxime chewable tablets was well accepted and safe.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28408213/