Peer-reviewed veterinary case report
Probiotic paste helps dogs recover faster from acute diarrhea
By Nixon, Sophie L et al.·Published in Journal of veterinary internal medicine·2019·ADM Protexin Ltd, United Kingdom·View original on PubMed →
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Original publication title: Efficacy of an orally administered anti-diarrheal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhea: A randomized, placebo-controlled, double-blinded clinical study.
- Species:
- dog
Plain-English summary
A study found that a probiotic paste called Pro-Kolin Advanced helped dogs with acute diarrhea recover faster than those given a placebo. In the study, 148 dogs with diarrhea were treated, and those receiving the probiotic had diarrhea for an average of 32 hours, compared to 47 hours for the placebo group. The probiotic also reduced the need for additional medical treatment, with only 3.5% of dogs needing more help compared to 14.8% in the placebo group. This suggests that using this probiotic can be an effective way to help dogs with diarrhea get better more quickly.
People also search for: dog diarrhea treatment · Pro-Kolin Advanced for dogs · how to help my dog with diarrhea
Abstract
BACKGROUND: Acute diarrhea is a common clinical presentation of dogs. The effect of specific anti-diarrheal probiotic pastes (ADPPs) in the management of acute, uncomplicated diarrhea in dogs is unknown. HYPOTHESIS: Administration of an ADPP containing Enterococcus faecium 4b1707 will improve the clinical outcome of acute, uncomplicated diarrhea in dogs compared to placebo. ANIMALS: One hundred forty-eight client-owned dogs with acute diarrhea as the main clinical sign. METHODS: Double-blinded, placebo-controlled, randomized, blocked, multicenter clinical field study conducted at 14 primary care veterinary practices in the United Kingdom and Ireland. RESULTS: The ADPP was associated with better clinical outcome compared to placebo in dogs with acute, uncomplicated diarrhea. Dogs in the ADPP group had a significantly shorter duration of diarrhea (ADPP: median, 32 hours; 95% confidence interval [CI], 2-118; n = 51; Placebo: median, 47 hours; 95% CI, 4-167; n = 58; P = .008) and the rate of resolution of diarrhea was 1.60 times faster in the ADPP group than in the Placebo group (ratio, 1.60; 95% CI, 1.08-2.44; P = .02). Fewer dogs required additional medical intervention (AMI) for non-improvement or worsening in the ADPP group compared to the Placebo group (3.5% of dogs and 14.8% of dogs, respectively), with a relative risk of 0.88 (P = .04; AMI, ADPP, 3.5%, 2/57 dogs; Placebo, 14.8%, 9/61 dogs; relative risk, 0.88; 95% CI, 0.77-0.99). CONCLUSION AND CLINICAL IMPORTANCE: The ADPP may accelerate resolution of acute diarrhea in dogs and decrease the requirement for AMI.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30882953/