Peer-reviewed veterinary case report
Combined cyclosporine and ketoconazole treat anal furunculosis in dogs
By O'Neill, T et al.·Published in The Journal of small animal practice·2004·Small Animal Hospital, United Kingdom·View original on PubMed →
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Original publication title: Efficacy of combined cyclosporine A and ketoconazole treatment of anal furunculosis.
- Species:
- dog
Plain-English summary
Nineteen dogs with anal furunculosis, a painful condition affecting the area around the anus, were treated with a combination of cyclosporine A and ketoconazole. Most dogs saw complete healing of their lesions within three to ten weeks, although some experienced recurrences after one to six months. While a few dogs had mild side effects like hair loss, lethargy, vomiting, and decreased appetite, these were not serious. Overall, this combined treatment was effective and more cost-efficient compared to using cyclosporine alone or opting for surgery.
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Abstract
Cyclosporine A and ketoconazole were used as a combined therapy to treat 19 dogs with anal furunculosis. Complete resolution of all lesions was achieved in three to 10 weeks, but recurrences occurred in seven of the 19 dogs (36.8 per cent), with remission periods extending from one to six months for these dogs. Adverse effects of treatment included excessive hair loss, intermittent lethargy, vomiting and decreased appetite in some dogs, but none of the signs were considered serious. The results of treatment are comparable with, if not better than, the surgical alternatives. There is an approximate 70 per cent cost saving over the use of cyclosporine alone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15163050/