Peer-reviewed veterinary case report
Spot-on with fipronil, amitraz, and methoprene kills adult dog fleas
By Bouhsira, Emilie et al.·Published in Veterinary parasitology·2011·Ecole Nationale Vé, France·View original on PubMed →
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Original publication title: Efficacy of fipronil, amitraz and (S)-methoprene combination spot-on for dogs against adult dog fleas (Ctenocephalides canis, Curtis, 1826).
- Species:
- dog
Plain-English summary
A group of adult Beagle dogs was treated with a new spot-on flea treatment that combines fipronil, amitraz, and (S)-methoprene to see how well it worked against dog fleas. After applying the treatment, the dogs showed excellent results, with a significant reduction in fleas within 24 hours and continued effectiveness for up to 7 weeks. This means that just one application can help keep your dog flea-free for a good amount of time. If your dog is struggling with fleas, this combination treatment could be a great option to discuss with your veterinarian.
People also search for: dog flea treatment · Beagle flea prevention · fipronil amitraz for dogs
Abstract
A novel spot-on formulation combining fipronil, amitraz and (S)-methoprene (CERTIFECT™, Merial Limited, GA, USA) was evaluated in adult Beagle dogs in a study to determine its adulticidal efficacy against the dog flea (Ctenocephalides canis, Curtis, 1826). Sixteen dogs were randomly allocated to treatment groups: 8 dogs served as untreated controls, and 8 dogs were treated once. Treatment consisted of applying a new combination formulation to deliver at least 6.7mg fipronil/kg body weight (bw), 8.0mg amitraz/kg bw, and 6.0mg (S)-methoprene/kg bw. The combination was designed to enhance the efficacy against ticks of the original fipronil/(S)-methoprene combination. Each dog was infested with 100 adult unfed dog fleas within 24h prior to treatment and then at weekly intervals for 8 weeks after treatment. At 24h after treatment or after each subsequent infestation, each dog was combed thoroughly to remove live fleas to be counted. A single treatment with CERTIFECT provided excellent knock-down of fleas within 24h after treatment and controlled re-infestations for up to 7 weeks (efficacy ≥96.5%, p<0.05).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21777738/