Peer-reviewed veterinary case report
Licofelone treatment reduces hindlimb lameness in dogs
By Moreau, M et al.·Published in The Veterinary record·2007·Veterinary Teaching Hospital Centre, Canada·View original on PubMed →
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Original publication title: Efficacy of licofelone in dogs with clinical osteoarthritis.
- Species:
- dog
Plain-English summary
A group of 33 dogs with limping due to hindlimb osteoarthritis were given either a placebo or a medication called licofelone for 28 days to see which helped more. The dogs that received licofelone showed a significant improvement in their ability to bear weight compared to those on the placebo, especially after two weeks. Both groups reported less lameness over time, but the licofelone-treated dogs had better results in terms of weight-bearing ability. Overall, licofelone appeared to help dogs with osteoarthritis feel more comfortable and move better.
People also search for: dog limping treatment · osteoarthritis in dogs · licofelone for dogs arthritis
Abstract
To evaluate the effect of licofelone, an arachidonic acid substrate with combined inhibitory activity against 5-lipoxygenase and cyclooxygenases 1 and 2, a double-blind, randomised and placebo-controlled study was conducted in 33 client-owned dogs that were lame owing to hindlimb osteoarthritis. Seventeen of the dogs received a placebo and 16 were treated with 2.5 mg/kg licofelone twice a day for 28 days. The dogs' lameness was assessed on a visual analogue scale (vas), and by force plate analyses at baseline and 14 and 28 days after starting the treatment. After 14 days the mean (se) change in peak vertical force in the licofelone-treated dogs (1.7 [0.8] per cent bodyweight) was significantly greater (P<0.05) than in the placebo-treated dogs (-0.3 [0.6] per cent bodyweight), and after 28 days the difference had increased. In contrast, the dogs' lameness, as assessed by the vas values, had decreased significantly over baseline in both the treated and control groups.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17468321/