Peer-reviewed veterinary case report
Long-term telmisartan lowers high blood pressure in cats
By Glaus, Tony M et al.·Published in Journal of veterinary internal medicine·2019·University of Zurich·View original on PubMed →
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Original publication title: Efficacy of long-term oral telmisartan treatment in cats with hypertension: Results of a prospective European clinical trial.
- Species:
- cat
Plain-English summary
A group of 285 cats with high blood pressure (hypertension) were treated with an oral solution of telmisartan to see if it could help lower their blood pressure. After 28 days, the cats receiving telmisartan showed a significant drop in their blood pressure compared to those given a placebo, with many reaching a healthier level. Specifically, the telmisartan group had an average reduction of about 24.6 mmHg, while the placebo group only saw a reduction of 11.4 mmHg. This suggests that telmisartan is an effective treatment for managing hypertension in cats.
People also search for: cat high blood pressure treatment · telmisartan for cats · symptoms of hypertension in cats
Abstract
BACKGROUND: Efficacy of telmisartan in treating hypertension (HT) in cats has not been largely investigated. OBJECTIVE: Telmisartan oral solution effectively controls systolic arterial blood pressure (SABP) in hypertensive cats. ANIMALS: Two-hundred eighty-five client-owned cats with systemic HT. METHODS: Prospective, multicenter, placebo-controlled, randomized, double-blinded study. Hypertensive cats diagnosed with SABP ≥160 mmHg and ≤200 mmHg without target-organ-damage were randomized (2 : 1 ratio) to receive 2 mg/kg telmisartan or placebo q24 PO. A 28-day efficacy phase was followed by a 120-day extended use phase. Efficacy was defined as significant difference in mean SABP reduction between telmisartan and placebo on Day 14 and group mean reduction in SABP of > 20 mmHg by telmisartan on Day 28 compared to baseline. RESULTS: Two-hundred fifty-two cats completed the efficacy and 144 cats the extended use phases. Mean SABP reduction at Day 14 differed significantly between groups (P < .001). Telmisartan reduced baseline SABP of 179 mmHg by 19.2 (95% confidence interval [CI]: 15.92-22.52) and 24.6 (95% CI: 21.11-28.14) mmHg at Days 14 and 28. The placebo group baseline SABP of 177 mmHg was reduced by 9.0 (95% CI: 5.30-12.80) and 11.4 (95% CI: 7.94-14.95) mmHg, respectively. Of note, 52% of telmisartan-treated cats had SABP <150 mmHg at Day 28. Mean SABP reduction by telmisartan in severe (≥180 mmHg) and moderate HT (160-179 mmHg) was comparable and persistent over time. CONCLUSIONS AND CLINICAL IMPORTANCE: Telmisartan solution (PO) was effective in reducing SABP in hypertensive cats with SABP ≥160 mmHg and ≤200 mmHg.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30561059/