Peer-reviewed veterinary case report
Nikkomycin Z treatment helps dogs with respiratory coccidioidomycosis
By Shubitz, Lisa F et al.·Published in Medical mycology·2013·* Department of Veterinary Science and Microbiology, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs.
- Species:
- dog
Plain-English summary
Twelve dogs with coccidioidomycosis, a fungal infection affecting their lungs, were treated with a medication called Nikkomycin Z for two months. These dogs had been suffering from respiratory issues for about three months before starting treatment. After the treatment, seven of the dogs showed improvement in their lung health, and three had nearly complete recovery. This suggests that Nikkomycin Z could be an effective option for treating this serious fungal infection in dogs.
People also search for: dog respiratory problems coccidioidomycosis treatment · Nikkomycin Z for dogs · dog lung infection symptoms
Abstract
Nikkomycin Z (NikZ) is a chitin synthase inhibitor with antifungal efficacy against Coccidioides spp. and other endemic fungi. Dogs suffer a rate and range of natural coccidioidomycosis similar to humans and were considered an excellent model for initially testing NikZ against naturally acquired disease. Twelve dogs with coccidioidal pneumonia that had been present for an average of three months were treated with 250 mg (5-15 kg) or 500 mg (> 15-30 kg) twice daily for 60 days. Nine dogs completed the course of treatment and seven dogs had improvement in disease based on radiographs, clinicopathological parameters, physical examination findings, and subjective assessment by owners; three dogs had resolution or near resolution of disease. Based on this small study, NikZ shows efficacy to treat naturally acquired coccidioidomycosis and merits further development for trials in humans.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23488972/