Peer-reviewed veterinary case report
Preventing exercise stomach inflammation in racing sled dogs
By Williamson, K K et al.·Published in Journal of veterinary internal medicine·2010·Department of Physiological Sciences, United States·View original on PubMed →
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Original publication title: Efficacy of omeprazole versus high-dose famotidine for prevention of exercise-induced gastritis in racing Alaskan sled dogs.
- Species:
- dog
Plain-English summary
A group of racing Alaskan sled dogs aged 2 to 8 years was studied to see how well two medications, omeprazole and famotidine, could prevent stomach problems caused by intense exercise. After running long distances, the dogs treated with omeprazole showed significantly fewer and less severe gastric lesions compared to those given famotidine. While famotidine did help reduce some stomach issues, omeprazole was found to be the more effective option for preventing gastritis in these active dogs. As a result, vets recommend using omeprazole for sled dogs to help protect their stomachs during races.
People also search for: sled dog stomach problems · omeprazole for dogs · famotidine for racing dogs · exercise-induced gastritis in dogs
Abstract
BACKGROUND: Omeprazole and famotidine both reduce severity of exercise-induced gastritis, but administering famotidine is easier than administering omeprazole during racing competition. HYPOTHESIS: Famotidine is more efficacious than no treatment in reducing severity of exercise-induced gastritis; and high-dose famotidine is more efficacious than omeprazole in reducing severity of exercise-induced gastritis. ANIMALS: Experiment 1: Randomized placebo-controlled study, 36 sled dogs (3-8 years); Experiment 2: Randomized positive-control study, 52 sled dogs (2-8 years). METHODS: Experiment 1: Equal numbers of dogs randomly assigned to famotidine (20 mg q24h) or no treatment groups. Gastroscopy was performed 24 hours after the dogs ran 330 miles. Mucosal appearance was blindly scored by previously described scoring system. Experiment 2: Equal numbers of dogs randomly assigned to omeprazole (20 mg q24h) or high-dose famotidine (40 mg q12h) groups. Gastroscopy was performed 48 hours before and 24 hours after the dogs ran 300 miles. Mucosal appearance was blindly scored by previously described scoring system. RESULTS: Famotidine reduced the prevalence of clinically relevant, exercise-induced gastric lesions compared with no treatment (7/16 versus 11/16, P = .031). Compared with high-dose famotidine, omeprazole significantly decreased the severity (0.4 versus 1.2, P = .0002) and prevalence (2/23 versus 7/21, P = .049) of gastric lesions. CONCLUSIONS AND CLINICAL RELEVANCE: Although famotidine provides some benefit in the prevention of exercise-induced gastric lesions, omeprazole is superior to famotidine in preventing gastritis in dogs running 300 miles. Routine administration of omeprazole is recommended to prevent stress-associated gastric disease in exercising and racing Alaskan sled dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20102495/