Peer-reviewed veterinary case report
Oral afoxolaner tablets effectively treat dog skin mite infection
By Beugnet, Frédéric et al.·Published in Parasite (Paris, France)·2016·Merial S.A.S., France·View original on PubMed →
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Original publication title: Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis.
- Species:
- dog
Plain-English summary
An 8-year-old mixed-breed dog was treated for generalized demodicosis, a skin condition caused by mites, using an oral medication called afoxolaner. Over two months, the dog received the chewable tablets at regular intervals, and the results showed a dramatic reduction in mite numbers and improvement in skin condition. By the end of the treatment, the mite counts were completely eliminated, while the other treatment option, a topical medication, was less effective. The dog’s skin improved significantly, indicating that afoxolaner is a highly effective treatment for this condition.
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Abstract
The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard(®), Merial) administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate(®), Bayer). Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg) on Days 0, 14, 28 and 56. The topical combination of imidacloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical examinations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The percentage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afoxolaner-treated group compared to the imidacloprid/moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with generalised demodicosis within a two-month period.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27012161/