Peer-reviewed veterinary case report
Oral afoxolaner plus milbemycin chewables kill Dermacentor ticks
By Rehbein, Steffen et al.·Published in Parasitology research·2016·Merial GmbH, Germany·View original on PubMed →
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Original publication title: Efficacy of oral afoxolaner plus milbemycin oxime chewables against induced infestations with Dermacentor reticulatus in dogs.
- Species:
- dog
Plain-English summary
A group of dogs was treated with either a combination of afoxolaner and milbemycin oxime chewables or afoxolaner alone to combat tick infestations caused by Dermacentor reticulatus ticks. Both treatments were highly effective, eliminating existing tick infestations within just two days and maintaining over 92% effectiveness against new ticks for at least five weeks. This means that if your dog is dealing with ticks, these chewable treatments can help keep them tick-free for an extended period.
People also search for: dog tick treatment · afoxolaner for ticks · milbemycin oxime chewables for dogs
Abstract
The efficacy of afoxolaner plus milbemycin oxime (AFX + MO) combination chewables (NexGard Spectra®, Merial) and AFX single-entity chewables (NexGard®, Merial) against induced infestations with Dermacentor reticulatus ticks was evaluated in dogs. Thirty dogs were assigned to blocks of three animals each based on pre-allocation tick counts and were randomly allocated to one of three groups: untreated (control), treated with a combination of AFX + MO chewables to be as close as possible to the minimum effective dose of AFX + MO (2.5 + 0.5 mg per kg body weight), and treated with a combination of NexGard® chewables to be as close as possible to the minimum effective dose of AFX (2.5 mg per kg body weight). Treatments were administered orally once on day 0. Starting 2 days before treatment administration, each dog was infested with approximately 50 ticks weekly for six consecutive weeks. Live ticks were counted at ∼48 h post-treatment (removal count) and at ∼48 h (in situ counts) and ∼72 h (removal counts) following each post-treatment infestation. Treatment with both AFX + MO and NexGard® chewables rapidly eliminated the existing tick infestations (100 % efficacy) within 2 days following treatment administration. Weekly re-infestations were controlled for a minimum of 5 weeks with the efficacy ranging from 92.2 to 99.7 % based on ∼48 h post-treatment in situ counts and between 99.0 and 100 % based on ∼72 h post-treatment removal counts (p < 0.0001 at each occasion). This study demonstrated a high efficacy of both AFX + MO chewable and NexGard® chewable treatments against infestations of dogs with D. reticulatus ticks for at least 5 weeks. In addition, this study indicated no interference between the two compounds with respect to the acaricidal activity provided by AFX.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26815036/