Peer-reviewed veterinary case report
Oral remdesivir and GS-441524 treat cats with effusive FIP equally
By Cosaro, Emma et al.·Published in Viruses·2023·William R. Pritchard Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: Efficacy of Oral Remdesivir Compared to GS-441524 for Treatment of Cats with Naturally Occurring Effusive Feline Infectious Peritonitis: A Blinded, Non-Inferiority Study.
- Species:
- cat
Plain-English summary
Eighteen cats with a serious condition called effusive feline infectious peritonitis (FIP) were treated with either GS-441524 or remdesivir, two antiviral medications. After 12 weeks of daily treatment, both medications showed similar effectiveness in helping the cats survive, with 55% of those on GS-441524 and 77% on remdesivir still alive at the end of the study. While three cats sadly passed away within the first 48 hours, the remaining cats had a high survival rate. Both treatments were found to be safe and effective, but improvements in the initial treatment period are needed for better outcomes.
People also search for: cat FIP treatment · remdesivir for cats · GS-441524 effectiveness in cats
Abstract
Nucleoside analogs GS-441524 and remdesivir (GS-5734) are effective in treating cats with feline infectious peritonitis (FIP). However, no studies have compared the efficacy between antiviral medications. The objective of this study was to evaluate the efficacy of orally administered GS-442514 (12.5-15 mg/kg) compared to orally administered remdesivir (25-30 mg/kg) in a double-blinded non-inferiority trial. Eighteen cats with effusive FIP were prospectively enrolled and randomly assigned to receive either GS-442514 or remdesivir. Cats were treated daily for 12 weeks and evaluated at week 0, 12, and 16. Survival and disease remission at week 16 were compared between groups. Five of 9 (55%) cats treated GS-441524 and 7/9 (77%) cats treated with remdesivir survived, with no difference in survival rate (= 0.2). Remdesivir fulfilled the criteria for non-inferiority with a difference in survival of 22% (90% CI; -13.5-57.5%). Three of the 18 cats died within 48 h of enrollment. Excluding these cats, 5/6 (83%) of the cats treated with GS-441524 and 7/9 (77%) of the cats treated with remdesivir survived. These findings suggest that both orally administered GS-441524 and remdesivir are safe and effective anti-viral medications for the treatment of effusive FIP. Further optimization of the first 48 h of treatment is needed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37632022/