Peer-reviewed veterinary case report
Maropitant given by mouth stops vomiting from hydromorphone in dogs
By Hay Kraus, Bonnie L·Published in Journal of the American Veterinary Medical Association·2014·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Efficacy of orally administered maropitant citrate in preventing vomiting associated with hydromorphone administration in dogs.
- Species:
- dog
Plain-English summary
A group of 40 dogs was given either a medication called maropitant or a placebo before receiving hydromorphone, a pain medication, to see if it would prevent vomiting. The results showed that none of the dogs who received maropitant vomited, while 25% of those who got the placebo did. However, many dogs in both groups showed signs of nausea, like salivation or lip-licking. Overall, maropitant was effective in preventing vomiting but did not stop the feeling of nausea.
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Abstract
OBJECTIVE: To evaluate the effectiveness of orally administered maropitant citrate in preventing vomiting after hydromorphone hydrochloride administration in dogs. DESIGN: Randomized, blinded, prospective clinical study. ANIMALS: 40 dogs with American Society of Anesthesiologists status of I or II, > 6 months of age, and weighing between 24 and 58.2 kg (52.8 and 128.04 lb). PROCEDURES: Dogs were randomly selected to receive maropitant (2.0 to 4.0 mg/kg [0.9 to 1.8 mg/lb]) or placebo (lactose monohydrate) orally 2 hours prior to receiving hydromorphone (0.1 mg/kg [0.045 mg/lb], IM). A blinded observer recorded the occurrence of vomiting or signs of nausea (eg, salivation or lip-licking) during a 30-minute period after hydromorphone administration. Two-tailed Fisher exact tests were used to compare the incidences of vomiting and signs of nausea with or without vomiting between treatment groups. Results-Of the 20 dogs receiving maropitant, none vomited but 12 (60%) developed signs of nausea. Of the 20 dogs receiving placebo, 5 (25%) vomited and 11 (55%) developed signs of nausea; overall, 16 of 20 (80%) dogs in the placebo treatment group vomited or developed signs of nausea. Compared with the effects of placebo, maropitant significantly decreased the incidence of vomiting but not signs of nausea in dogs administered hydromorphone. CONCLUSIONS AND CLINICAL RELEVANCE: Among the 40 study dogs, the incidence of vomiting associated with hydromorphone administration was 25%. Oral administration of maropitant prevented vomiting but not signs of nausea associated with hydromorphone administration in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24786163/