Peer-reviewed veterinary case report
Revolution Plus topical kills lone star ticks on cats
By Holzmer, Susan et al.·Published in Parasites & vectors·2025·Zoetis, United States·View original on PubMed →
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Original publication title: Efficacy of Revolution® Plus (selamectin plus sarolaner) against Amblyomma americanum (lone star ticks) in cats.
- Species:
- cat
Plain-English summary
A group of domestic short-hair cats was tested for tick control using a topical treatment called Revolution Plus, which contains selamectin and sarolaner. The cats were infested with lone star ticks and then treated with either the medication or a placebo. The results showed that the cats treated with Revolution Plus had significantly fewer ticks compared to those that received the placebo, with over 90% effectiveness in reducing tick counts. This treatment was effective for at least a month without causing any adverse reactions.
People also search for: cat tick treatment · Revolution Plus for cats · lone star tick control in cats
Abstract
BACKGROUND: The efficacy of a topical combination product, Revolution® Plus, containing selamectin and sarolaner was evaluated for efficacy against Amblyomma americanum ticks in cats. METHODS: Four laboratory dose confirmation efficacy studies were conducted in different geographical regions of the USA using three distinct US isolates of A. americanum. In each study, ten domestic short-hair cats were randomly allocated to each treatment group based on pretreatment host-suitability tick counts. Cats were infested with approximately 50 unfed adult ticks on day -2. On day 0, cats received either a topical placebo or a single topical dose of Revolution® Plus at the minimum dosage of 6.0 mg/kg selamectin + 1.0 mg/kg sarolaner. Cats were re-infested with approximately 50 unfed adult ticks each on days 5, 12, 19, 26, and 33. Tick counts (comprising live attached and live free ticks) were conducted at 72 h post-treatment and after each subsequent weekly re-infestation. RESULTS: No treatment-related adverse reactions occurred in any study. In all studies, placebo-treated cats maintained adequate infestations for the entire study duration, and cats treated with Revolution® Plus had significantly lower (P < 0.0001) least squares mean live (attached and free) tick counts than placebo-treated cats at all time points for at least 1 month. Revolution® Plus provided a mean of > 90% effectiveness based on least squares means 72 h after treatment of existing infestations, and maintained > 99.1% effectiveness 72 h after re-infestation through at least day 29. CONCLUSIONS: A single dose of Revolution® Plus administered topically at the minimum label dose of 6.0 mg/kg selamectin + 1.0 mg/kg sarolaner provided treatment and control of A. americanum on cats for at least 1 month.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40750907/