Peer-reviewed veterinary case report
Efficacy of Rg1-Oil Adjuvant on Inducing Immune Responses againstin Rabbits.
- Journal:
- Journal of immunology research
- Year:
- 2021
- Authors:
- Chenwen, Xiao et al.
- Affiliation:
- Institute of Animal Husbandry and Veterinary Science · China
- Species:
- rabbit
Abstract
(.) is an obligately aerobic, oxidase- and catalase-positive, nonfermentative Gram-negative coccobacillus. This study is aimed at examining the immune effects of Rg1, Rg1 plus oil, and other common adjuvants on inactivated.vaccine in rabbits. The mechanism underlying the adjuvant effect of Rg1 plus oil on the vaccine was also explored. Rg1 (100 g) plus oil significantly improved the immune effect of.vaccine at both the humoral and cellular levels. Rg1-oil adjuvant increased the levels of IL-2 and IL-4 in rabbits after immunization. Rg1 (100 g) plus oil also significantly increased TLR2 expression and downregulated NF-B in splenocytes. Rg1-oil adjuvant may increase the levels of IL-2 and IL-4 via upregulating TLR2, thereby enhancing the immune effect of.vaccine. In conclusion, Rg1 plus oil could be used as a potential vaccine adjuvant for rabbit.vaccine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33575363/