Peer-reviewed veterinary case report
Ronidazole treatment clears Tritrichomonas foetus infection in cats
By Lim, Sun et al.·Published in The Korean journal of parasitology·2012·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Efficacy of ronidazole for treatment of cats experimentally infected with a Korean isolate of Tritrichomonas foetus.
- Species:
- cat
Plain-English summary
Three kittens were intentionally infected with a parasite called Tritrichomonas foetus to test a medication called ronidazole. After 30 days, the kittens were split into two groups: one group received ronidazole for 14 days, while the other group received a placebo. The kittens treated with ronidazole showed no signs of the parasite in their feces during and after treatment, while the control group continued to test positive. This suggests that ronidazole is effective in treating Tritrichomonas foetus infections in cats.
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Abstract
To evaluate the efficacy of ronidazole for treatment of Tritrichomonas foetus infection, 6 Tritrichomonas-free kittens were experimentally infected with a Korean isolate of T. foetus. The experimental infection was confirmed by direct microscopy, culture, and single-tube nested PCR, and all cats demonstrated trophozoites of T. foetus by day 20 post-infection in the feces. From day 30 after the experimentally induced infection, 3 cats were treated with ronidazole (50 mg/kg twice a day for 14 days) and 3 other cats received placebo. Feces from each cat were tested for the presence of T. foetus by direct smear and culture of rectal swab samples using modified Diamond's medium once a week for 4 weeks. To confirm the culture results, the presence of T. foetus rRNA gene was determined by single-tube nested PCR assay. All 3 cats in the treatment group receiving ronidazole showed negative results for T. foetus infection during 2 weeks of treatment and 4 weeks follow-up by all detection methods used in this study. In contrast, rectal swab samples from cats in the control group were positive for T. foetus continuously throughout the study. The present study indicates that ronidazole is also effective to treat cats infected experimentally with a Korean isolate of T. foetus at a dose of 50 mg/kg twice a day for 14 days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22711930/