Peer-reviewed veterinary case report
Sarolaner oral treatment kills Amblyomma cajennense ticks on dogs
By Scott, Fabio et al.·Published in Parasites & vectors·2017·Programa de Pó, Brazil·View original on PubMed →
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Original publication title: Efficacy of sarolaner (Simparic™) against induced infestations of Amblyomma cajennense on dogs.
- Species:
- dog
Plain-English summary
A group of dogs was treated with a single oral dose of sarolaner (Simparica) to see how well it worked against ticks that can carry diseases. The study found that this treatment was highly effective, eliminating 100% of the ticks within just a couple of days and maintaining over 99% effectiveness for up to 35 days. Importantly, there were no side effects reported from the treatment. This means that sarolaner is a reliable option for protecting dogs from tick infestations.
People also search for: dog tick prevention · Simparica for dogs · how to treat ticks on dogs
Abstract
BACKGROUND: Amblyomma cajennense is the main vector of Rickettsia rickettsii which causes Brazilian spotted fever. This adult tick preferably infests horses and capybaras, but has low host specificity during its immature stages, thus posing a threat to humans and dogs. In this study, the efficacy of sarolaner (Simparic™/Simparica®, Zoetis) when administered once orally to dogs at 2 mg/kg was evaluated against induced infestations of A. cajennense nymphs for up to 35 days after treatment. METHODS: Based on pretreatment tick counts, 20 dogs were randomly allocated to treatment with sarolaner (Simparic™) dosed at 2 mg/kg of body weight or a placebo on Day 0 of the study. Artificial infestations were performed using laboratory raised A. cajennense nymphs on study days -2, 5, 12, 19, 26 and 33. Efficacy was determined at 48 h post-treatment or post-infestation at each time point relative to the counts for dogs that received placebo. RESULTS: There were no adverse reactions to treatment. A single dose of sarolaner (Simparic™) provided 100% efficacy on study days 2, 7 and 14; and ≥ 99.6% on days 21, 28 and 35. Geometric mean live tick counts for sarolaner were significantly lower than those for placebo on all days (P < 0.0001). CONCLUSIONS: Under the conditions of the present study, sarolaner (Simparic™) administered once orally at 2 mg/kg provided 100% efficacy against existing infestations and ≥ 99.6% efficacy within 48 h against weekly challenges of A. cajennense for at least 35 days after treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28814323/