Peer-reviewed veterinary case report
Sarolaner (Simparica) kills Haemaphysalis longicornis ticks on dogs
By Oda, Kenji et al.·Published in Parasites & vectors·2019·Research Institute for Animal Science in Biochemistry and Toxicology, Japan·View original on PubMed →
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Original publication title: Efficacy of sarolaner (Simparica) against induced infestations of Haemaphysalis longicornis on dogs.
- Species:
- dog
Plain-English summary
A group of dogs with tick infestations were treated with a single dose of sarolaner (Simparica) to see how well it worked against the Haemaphysalis longicornis tick. The treatment showed 100% effectiveness in eliminating the ticks for at least 35 days, with no side effects reported. This means that if your dog has ticks, giving them sarolaner can effectively clear the infestation and help prevent new ones from taking hold.
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Abstract
BACKGROUND: Haemaphysalis longicornis is the major tick affecting dogs in most of the East Asia/Pacific region and has recently been detected in a number of areas of the USA. This tick is a vector for a number of pathogens of dogs, other mammals and humans. In this study, the efficacy of a single oral administration of sarolaner (Simparica, Zoetis) at the minimum label dosage (2 mg/kg) was evaluated against an existing infestation of H. longicornis and subsequent weekly reinfestations for 5 weeks after treatment. METHODS: Sixteen dogs were ranked on pretreatment tick counts and randomly allocated to treatment on Day 0 with sarolaner at 2 mg/kg or a placebo. The dogs were infested with H. longicornis nymphs on Days - 2, 5, 12, 19, 26 and 33. Efficacy was determined at 48 hours after treatment and subsequent re-infestations based on live tick counts relative to placebo-treated dogs. RESULTS: There were no adverse reactions to treatment. A single dose of sarolaner provided 100% efficacy on Days 2, 7, 14 and 21; and ≥ 97.4% efficacy on Days 28 and 35. Considering only attached, live ticks, efficacy was 100% for the entire 35 days of the study. Geometric mean live tick counts for sarolaner were significantly lower than those for placebo on all days (11.62 ≤ t ≤ 59.99, where 13.0 ≤ df ≤ 14.1, P < 0.0001). CONCLUSIONS: In this study, a single oral administration of sarolaner at 2 mg/kg provided 100% efficacy against an existing infestation of H. longicornis nymphs and ≥ 97.4% efficacy (100% against attached ticks) against weekly reinfestation for at least 35 days after treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31666109/