Peer-reviewed veterinary case report
Souroubea-Platanus supplement reduces thunderstorm anxiety in beagles
By Masic, Aleksandar et al.·Published in Molecules (Basel, Switzerland)·2021·Department of Microbiology·View original on PubMed →
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Original publication title: Efficacy of Souroubea-Platanus Dietary Supplement Containing Triterpenes in Beagle Dogs Using a Thunderstorm Noise-Induced Model of Fear and Anxiety.
- Species:
- dog
Plain-English summary
A group of 60 Beagle dogs experiencing anxiety from thunderstorm noises were given a new chewable dietary supplement containing a natural ingredient called betulinic acid. The dogs were divided into groups receiving different doses of the supplement or a placebo for five days. The results showed that the dogs receiving the supplement had less anxiety, as indicated by increased activity levels and lower cortisol (a stress hormone) compared to those on the placebo. This suggests that the supplement could be helpful for dogs that get stressed during storms.
People also search for: dog thunderstorm anxiety treatment · Beagle anxiety supplements · natural remedies for dog stress
Abstract
A novel botanical dietary supplement, formulated as a chewable tablet containing a defined mixture ofspp. vine andspp. Bark, was tested as a canine anxiolytic for thunderstorm noise-induced stress (noise aversion). The tablet contained five highly stable triterpenes and delivered 10 mg of the active ingredient betulinic acid (BA) for an intended 1 mg/kg dose in a 10 kg dog. BA in tablets was stable for 30 months in storage at 23 °C. Efficacy of the tablets in reducing anxiety in dogs was assessed in a blinded, placebo-controlled study by recording changes in blood cortisol levels and measures of behavioral activity in response to recorded intermittent thunder. Sixty beagles were assigned into groups receiving: placebo, 0.5×, 1×, 2×, and 4× dose, or the positive control (diazepam), for five days. Reduction in anxiety measures was partially dose-dependent and the 1× dose was effective in reducing inactivity time (= 0.0111) or increased activity time (= 0.0299) compared with placebo, indicating a decrease in anxiety response. Cortisol measures also showed a dose-dependent reduction in cortisol in dogs treated with the test tablet.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33916654/