Peer-reviewed veterinary case report
Efficacy of telavancin against penicillin-resistant pneumococci and Staphylococcus aureus in a rabbit meningitis model and determination of kinetic parameters.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2006
- Authors:
- Stucki, Armin et al.
- Affiliation:
- Department of Internal Medicine
- Species:
- rabbit
Abstract
The penetration of telavancin was 2% into inflamed meninges and ca. 1 per thousand into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16436742/