Peer-reviewed veterinary case report
Effectiveness of Tigecycline and Linezolid on Drug-Resistant Bacteria
By Kim, Dong-Hyun & Kim, Jung-Hyun·Published in Frontiers in veterinary science·2021·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Efficacy of Tigecycline and Linezolid Against Pan-Drug-Resistant Bacteria Isolated From Companion Dogs in South Korea.
- Species:
- dog
Plain-English summary
A study found that two antibiotics, tigecycline and linezolid, were effective against certain drug-resistant bacteria found in dogs. Researchers collected samples from dogs with various infections, including skin and ear issues, and discovered that many bacteria were resistant to all known treatments. However, nearly all tested gram-positive bacteria responded well to both antibiotics, and a significant number of gram-negative bacteria were also sensitive to tigecycline. This suggests that these antibiotics could be valuable options for treating infections in dogs that are resistant to other medications.
People also search for: dog skin infection treatment · antibiotic resistance in dogs · tigecycline for dogs · linezolid for dog infections
Abstract
The emergence of multidrug-resistant bacteria in companion animals is an increasing concern in view of the concept of One Health. The antimicrobials linezolid (LZD) and tigecycline (TGC) are effective against multidrug-resistant bacteria isolated from humans; however, thus far, no previous study has evaluated the efficacy of these drugs against bacteria isolated from companion animals. This study aimed to evaluate the efficacy of LZD and TGC against bacteria that were isolated from companion dogs and showed resistance to all classes of antimicrobial agents. Clinical samples (auditory channel, eye, skin, and urine) were collected from dogs that visited the Veterinary Medical Teaching Hospital of Konkuk University (Seoul, South Korea) from October 2017 to September 2020. In total, 392 bacterial isolates were obtained, of which 85 were resistant to all classes of antimicrobial agents tested and were, therefore, considered potentially pan-drug resistant (PDR). The susceptibility of isolates to LZD and TGC was determined by the disk diffusion method and interpreted using the Clinical Laboratory Standards Institute guidelines. In total, 95.6% (43/45) and 97.8% (44/45) of gram-positive isolates were susceptible to LZD and TGC, respectively, whereas 82.5% (33/40) of gram-negative isolates were sensitive to TGC. In conclusion, both agents showed favorable efficacy, with the susceptibility rates for all potential PDR bacteria, exceptspp., ranging from 72.7 to 100%. Thus, these drugs may serve as excellent antimicrobial options for veterinary medicine in the future.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34422945/