Peer-reviewed veterinary case report
Low-dose tylosin controls diarrhea relapse in dogs
By Kilpinen, Susanne et al.·Published in Acta veterinaria Scandinavica·2014·View original on PubMed →
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Original publication title: Efficacy of two low-dose oral tylosin regimens in controlling the relapse of diarrhea in dogs with tylosin-responsive diarrhea: a prospective, single-blinded, two-arm parallel, clinical field trial.
- Species:
- dog
Plain-English summary
A group of dogs with diarrhea that responded to tylosin treatment were given either a low dose of 5 mg/kg or a slightly higher dose of 15 mg/kg to see which worked better for preventing a relapse. All eight dogs on the 5 mg/kg dose improved, and six out of seven on the 15 mg/kg dose also showed positive results. The study suggests that a daily dose of 5 mg/kg for a week could effectively control diarrhea relapses in dogs with this condition.
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Abstract
BACKGROUND: Despite its wide acceptance as a treatment for canine chronic enteropathies, the macrolide antibiotic tylosin lacks official oral dosage recommendations. Not even textbooks share consensus about the dose; daily recommendations vary from 25 to 80 mg/kg and dosing intervals from one to three times daily. RESULTS: All eight dogs responded to the 5 mg/kg dose, and six of seven dogs responded to the 15 mg/kg dose. The mean fecal consistency scores at the 25 mg/kg tylosin dosage were no significantly different from scores at the 5 mg/kg or 15 mg/kg tylosin dosages (P=0.672, P=0.345). CONCLUSIONS: Interestingly, 14/15 (93%) of the dogs responding to a dose of 25 mg/kg tylosin once daily for seven days also responded to the lower dosages at diarrhea relapse. The data indicate that a suitable dose of tylosin for treating diarrhea relapse in canine TRD could be as low as 5 mg/kg once daily for seven days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25096196/