Peer-reviewed veterinary case report
Vincristine treatment results for dogs with histiocytic sarcoma
By Sakuma, Hiroki et al.·Published in The Journal of veterinary medical science·2024·Department of Veterinary Medical Sciences, Japan·View original on PubMed →
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Original publication title: Efficacy of vincristine as a rescue therapy for canine histiocytic sarcoma.
- Species:
- dog
Plain-English summary
A group of dogs with a serious type of cancer called histiocytic sarcoma (CHS) were treated with a chemotherapy drug called vincristine after they stopped responding to other treatments. Out of nine dogs, one went into complete remission, two had partial remission, five showed stable disease, and one continued to worsen. The dogs that responded had a median time without disease progression of about three weeks. However, one dog experienced a severe side effect, which was a significant drop in platelets. This study highlights the need for better treatment options for this aggressive cancer.
People also search for: dog histiocytic sarcoma treatment · vincristine for dog cancer · canine cancer chemotherapy side effects
Abstract
Canine histiocytic sarcoma (CHS) is a malignant tumor derived from macrophages and dendritic cells. Since effective chemotherapy is needed for CHS cases, we conducted this prospective study to evaluate the efficacy and adverse events of vincristine treatment as a rescue therapy for this disease. We administered vincristine to nine CHS cases that acquired resistance to lomustine or nimustine. Complete remission was achieved in one dog, partial remission in two dogs, stable disease in five dogs, and progressive disease in one dog. The median progression-free survival was 21 days (range: 7-71 days). Severe adverse effect was observed in one dog (Grade 3 thrombocytopenia). It is essential to establish novel effective treatments for CHS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39198188/