Peer-reviewed veterinary case report
Fatal artery rupture in 7-month-old dog with Ehlers-Danlos syndrome
By Uri, M et al.·Published in Journal of comparative pathology·2015·Small Animal Veterinary Teaching Hospital, United Kingdom·View original on PubMed →
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Original publication title: Ehlers-Danlos syndrome associated with fatal spontaneous vascular rupture in a dog.
- Species:
- dog
Plain-English summary
A 7-month-old male crossbreed dog was brought to the vet with very stretchy skin and unusual scars. He was diagnosed with Ehlers-Danlos syndrome, a condition that affects collagen in the body. Sadly, two weeks later, the dog died suddenly, and a post-mortem exam showed that a blood vessel had ruptured, leading to internal bleeding. This case highlights how Ehlers-Danlos syndrome can also affect blood vessels, which is rare in animals.
People also search for: dog stretchy skin condition · Ehlers-Danlos syndrome in dogs · sudden death in young dog · dog blood vessel rupture symptoms
Abstract
A 7-month-old male cross breed dog was presented with hyperextensible skin and atrophic scarring. A diagnosis of Ehlers-Danlos syndrome was made based on clinical signs, histopathology and electron microscopy. Two weeks after presentation, the dog died suddenly. Post-mortem examination revealed haemothorax and rupture of the left subclavian artery. Histological findings, including Goldner's modified Masson's trichrome staining and transmission electron microscopy of the subclavian artery, revealed abnormalities in the structure and arrangement of collagen fibrils, suggesting that the defective collagen formation extended to the vasculature. To the authors' knowledge, this is the first report of Ehlers-Danlos syndrome with vascular involvement in animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25680848/