Peer-reviewed veterinary case report
Electroporation treatments for oral tumors in small animals
By Nemec, Ana et al.·Published in Frontiers in veterinary science·2020·Small Animal Clinic·View original on PubMed →
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Original publication title: Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology.
- Species:
- dog
Plain-English summary
A dog with an oral tumor, such as squamous cell carcinoma or malignant melanoma, may be treated with a method called electroporation, which helps deliver chemotherapy directly into the cancer cells. This treatment is safe, quick, and cost-effective, especially for tumors that can't be surgically removed. Many dogs that received electroporation showed good responses, leading to longer survival times and better quality of life. However, more research is needed to refine the treatment and understand how it works best.
People also search for: dog oral tumor treatment · electroporation for dog cancer · squamous cell carcinoma in dogs · melanoma treatment for dogs
Abstract
Electroporation is a method of inducing an increase in permeability of the cell membrane through the application of an electric field and can be used as a delivery method for introducing molecules of interest (e.g., chemotherapeutics or plasmid DNA) into cells. Electroporation-based treatments (i.e., electrochemotherapy, gene electrotransfer, and their combinations) have been shown to be safe and effective in veterinary oncology, but they are currently mostly recommended for the treatment of those solid tumors for which clients have declined surgery and/or radiotherapy. Published data show that electroporation-based treatments are also safe, simple, fast and cost-effective treatment alternatives for selected oral and maxillofacial tumors, especially small squamous cell carcinoma and malignant melanoma tumors not involving the bone in dogs. In these patients, a good local response to treatment is expected to result in increased survival time with good quality of life. Despite emerging evidence of the clinical efficacy of electroporation-based treatments for oral and maxillofacial tumors, further investigation is needed to optimize treatment protocols, improve clinical data reporting and better understand the mechanisms of patients' response to the treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33134356/