Peer-reviewed veterinary case report
Early cone-rod eye disease in Standard Wire Haired Dachshunds seen
By Ropstad, Ernst O et al.·Published in Documenta ophthalmologica. Advances in ophthalmology·2007·Department of Companion Animal Clinical Sciences·View original on PubMed →
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Original publication title: Electroretinographic findings in the Standard Wire Haired Dachshund with inherited early onset cone-rod dystrophy.
- Species:
- dog
Plain-English summary
A group of Standard Wire Haired Dachshunds was studied for early signs of a genetic eye condition called cone-rod dystrophy, which affects their vision. At around 5 weeks old, these dogs showed significant differences in their eye responses compared to healthy dogs, indicating that their vision was already impaired. As they aged, the affected dogs did not show the same improvements in vision that healthy dogs did. This research highlights that these dogs can experience vision problems from a very young age, and it’s important for owners to monitor their pets for any signs of eye issues.
People also search for: Standard Wire Haired Dachshund eye problems · dog vision issues · inherited eye disease in dogs · early onset cone-rod dystrophy in dogs
Abstract
PURPOSE: To describe electroretinographic (ERG) findings in a strain of Standard Wire Haired Dachshund (SWHD)-derived dogs at the ages of approximately 5, 8 and 52 weeks selected for inherited early onset cone-rod dystrophy. METHODS: Nineteen affected and 13 age-matched control SWHDs were included in the study. All dogs were subjected to standardized bilateral Ganzfeld ERGs and ophthalmoscopic examinations at regular intervals. RESULTS: Photopic cone-derived ERG amplitudes were significantly lower and never reached similar levels as those recorded in control dogs. In affected dogs there was no increase with age in amplitudes recorded using 30.1 and 50.1 Hz flicker stimuli. In contrast, in the control groups the photopic b-wave amplitude recorded at 50.1 Hz increased significantly from age 5 to 8 and from 5 to 52 weeks. In affected animals, scotopic rod-derived amplitudes were significantly lower for most recordings compared to those of control dogs, although they increased significantly from age 5 to 8 weeks in both affected and controls. Both a- and b-wave implicit times were significantly longer in the youngest affected group when compared to the age-matched control group at 0.6 log cd s/m(2) and 5.1 Hz single flash light stimuli. In the control dogs, however, there was a significant shortening in a-wave implicit times from age 5 to 8 weeks, and in a- and b-wave implicit times recorded at 5.1 Hz single flash stimuli from age 5 to 52 weeks. CONCLUSIONS: The described retinal degeneration in the SWHD is an early onset cone-rod dystrophy, initially affecting the cone system most severely. Early functional changes are seen in the rod system as well. Inner retina also appears affected already at a young age with findings indicating postsynaptic functional changes already at the earliest time point studied, at age 5 weeks. The present study further indicates that the canine retina reaches maturity later than previously reported, or that there exist major breed differences.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17180612/