Peer-reviewed veterinary case report
High pancreatic lipase linked to worse outcomes in dogs
By Kathrani, A et al.·Published in The Journal of small animal practice·2009·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Elevated canine pancreatic lipase immunoreactivity concentration in dogs with inflammatory bowel disease is associated with a negative outcome.
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) had their blood tested for a specific enzyme called pancreatic lipase. The results showed that dogs with higher levels of this enzyme were older and had more severe disease. Unfortunately, these dogs did not respond well to steroid treatments and were more likely to be euthanized later on. This suggests that measuring pancreatic lipase levels can help veterinarians understand the severity of IBD in dogs and predict their outcomes.
People also search for: dog inflammatory bowel disease treatment · elevated pancreatic lipase in dogs · IBD in dogs prognosis
Abstract
OBJECTIVES: To investigate whether elevated canine pancreatic lipase immunoreactivity (CPLI) concentrations in dogs with inflammatory bowel disease (IBD) is associated with a worse clinical outcome. METHODS: Serum CPLI assays were performed on serum stored from cases diagnosed with IBD. Thirty-two dogs with CPLI results within the reference range were designated as the control group and 15 dogs had CPLI above the reference range. Clinical signs, age, serum lipase and amylase activities, serum albumin and cobalamin concentrations, abdominal ultrasound examination, histopathology on small intestinal biopsies, management of IBD and outcome were compared between the two groups. RESULTS: No significant differences were found in clinical activity score (P=0.54), number of antibiotic-responsive disease cases (P=0.480), number of steroid-responsive disease cases (P=0.491), serum amylase activity (P=0.058), serum cobalamin concentration (P=0.61), serum albumin concentration (P=0.052), abdominal ultrasound score (P=0.23) and histopathology scores for IBD (P=0.74) between the two groups. Dogs with increased CPLI concentration were significantly older and had a higher serum lipase activity than dogs with a CPLI concentration within the normal reference range (P=0.001, P=0.001, respectively). Moreover, dogs with increased CPLI concentration responded poorly to steroid treatment (P=0.01) and were significantly more likely to be euthanased at follow-up (P=0.02). CLINICAL SIGNIFICANCE: CPLI should be measured in cases of canine IBD as elevated CPLI was associated with a worse outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19261082/