Peer-reviewed veterinary case report
High creatinine and low sodium predict worse outcomes in dogs
By Marchetti, V et al.·Published in Australian veterinary journal·2017·Veterinary Teaching Hospital "Mario Modenato", Italy·View original on PubMed →
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Original publication title: Elevated serum creatinine and hyponatraemia as prognostic factors in canine acute pancreatitis.
- Species:
- dog
Plain-English summary
A group of 50 dogs diagnosed with acute pancreatitis (AP) showed that high levels of creatinine and low sodium levels in their blood were linked to a worse chance of recovery. Dogs with sodium levels below 139 mmol/L and creatinine levels above 212 µmol/L had a significantly higher risk of dying from the condition. These findings suggest that monitoring these blood values can help veterinarians predict outcomes in dogs suffering from AP. Early intervention and treatment based on these factors could potentially improve survival rates.
People also search for: dog pancreatitis symptoms · elevated creatinine in dogs · low sodium levels in dogs
Abstract
OBJECTIVE: To evaluate prognostic factors for canine acute pancreatitis (AP) based on clinical and laboratory data that can be easily assessed in veterinary practice. DESIGN: Retrospective study between January 2010 and December 2013. METHODS: The diagnosis of AP was based on clinical signs and an abnormal SNAP® cPL™ test result, concurrently with an ultrasound pattern suggestive of pancreatitis. Dogs were divided into survivors and non-survivors. We evaluated 12 clinical and laboratory parameters: respiratory rate, rectal temperature, white blood cells, haematocrit, total serum proteins, albumin, creatinine, cholesterol, total and ionised calcium, sodium and potassium. Clinical and clinicopathological data were statistically compared between survivors and non-survivors. A value of P < 0.05 was considered significant and P < 0.01 as highly significant. The odds ratio (OR) was calculated. RESULTS: The study enrolled 50 client-owned dogs with a diagnosis of AP. Serum creatinine (P = 0.017) and sodium (P = 0.004) correlated significantly with the outcome. Serum sodium < 139.0 mmol/L (139.0 mEq/L) and serum creatinine > 212 μmol/L (2.4 mg/dL) were associated significantly with poor prognosis. Azotaemia (OR 12.5; 95% confidence interval (CI) 1.32-118.48) and hyponatraemia (OR 4.9; 95% CI 1.36-17.64) were associated with increased risk of death. CONCLUSIONS: In dogs with AP, hyponatraemia and azotaemia seem to be significantly associated with an increased risk of death.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29076217/